Global Circumferential and Radial Strain Among Patients With Immune Checkpoint Inhibitor Myocarditis.

ABSTRACT:

Background

Global circumferential strain (GCS) and global radial strain (GRS) are reduced with cytotoxic chemotherapy. There are limited data on the effect of immune checkpoint inhibitor (ICI) myocarditis on GCS and GRS.

Objectives

This study aimed to detail the role of GCS and GRS in ICI myocarditis.

Methods

In this retrospective study, GCS and GRS from 75 cases of patients with ICI myocarditis and 50 ICI-treated patients without myocarditis (controls) were compared. Pre-ICI GCS and GRS were available for 12 cases and 50 controls. Measurements were performed in a core laboratory blinded to group and time. Major adverse cardiovascular events (MACEs) were defined as a composite of cardiogenic shock, cardiac arrest, complete heart block, and cardiac death.

Results

SUBMITTER: Quinaglia T 

PROVIDER: S-EPMC10334352 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature