Pivotal role of the protein corona in the cell uptake of fluorinated nanoparticles with increased sensitivity for ¹⁹F-MR imaging.

ABSTRACT: In vivo cell tracking by non-invasive imaging technologies is needed to accelerate the clinical translation of innovative cell-based therapies. In this regard, ¹⁹F-MRI has recently gained increased attention for unbiased localization of labeled cells over time. To push forward the use of ¹⁹F-MRI for cell tracking, the development of highly performant ¹⁹F-probes is required. PLGA-based NPs containing PERFECTA, a multibranched superfluorinated molecule with an optimal MRI profile thanks to its 36 magnetically equivalent fluorine atoms, are promising ¹⁹F-MRI probes. In this work we demonstrate the importance of the surface functionalization of these NPs in relation to their interaction with the biological environment, stressing the pivotal ro

SUBMITTER: Gatti L 

PROVIDER: S-EPMC10334373 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature