Sex Differences in the Association Between Serum Testosterone and Kidney Function in the General Population.

ABSTRACT:

Introduction

Testosterone might prevent kidney function decline, although evidence is limited in men and lacking in women from the general population. We investigated the association between serum testosterone and kidney function in men and women from a large population-based cohort study.

Methods

Participants aged ≥45 years with available measurements of serum testosterone, sex hormone-binding globulin (SHBG), creatinine, and cystatine C were included. Assessments of kidney function included baseline assessments of the estimated glomerular filtration rate (eGFR) based on serum creatinine (eGFRcreat) or serum cystatin C (eGFRcys), and the urine albumin-to-creatinine ratio (ACR), and repeated assessments of eGFRcreat. Linear regression and linear mixed models were used to ass

SUBMITTER: van der Burgh AC 

PROVIDER: S-EPMC10334405 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature