A Light-Promoted Innate Trifluoromethylation of Pyridones and Related N-Heteroarenes.

ABSTRACT: We report a practical, light-mediated perfluoroalkylation using Langlois' reagent (sodium trifluoromethylsulfinate) that proceeds in the absence of any photocatalyst or additives. This method has allowed for the facile functionalization of pyridones and related N-heteroarenes such as azaindole. This protocol is operationally simple, uses readily available materials, and is tolerable for electron-neutral and -rich functional pyridones. Cyclic voltammetry was utilized as a mechanistic probe, and preliminary data suggest the reaction may involve an electrophilic radical mechanism.

SUBMITTER: Dang-Nguyen A 

PROVIDER: S-EPMC10334463 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature