Pregnancy-associated Steroid Effects on Insulin Sensitivity, Adipogenesis, and Lipogenesis: Role of Wnt/β-Catenin Pathway.

ABSTRACT:

Context

The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. Imbalances in circulating estradiol (E₂) and progesterone (P₄) levels during this period are often associated with metabolic disturbances leading to the development of gestational diabetes mellitus (GDM). Since abnormalities in the Wnt pathway effector transcription factor 7-like 2 (TCF7L2) are commonly associated with the occurrence of GDM, we hypothesized that the canonical or β-catenin-dependent Wnt signaling pathway mediates the metabolic actions of E₂ and P₄.

Objective

Our study was aimed at elucidating the metabolic function of the steroids E₂

SUBMITTER: Alex NS 

PROVIDER: S-EPMC10334487 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature