Th1 cells inducing IFNγ response improves immunotherapy efficacy in gastric cancer.

ABSTRACT:

Objective

Cancer immunotherapy has made remarkable advances in recent years, but its effectiveness in treating gastric cancer is often limited by the complexity of the tumor microenvironment and the lack of effective biomarkers. This study aimed to identify effective biomarkers for immunotherapy treatment by characterizing the tumor microenvironment.

Methods

We retrieved the RNA-seq data from gastric cancer patients treated with the programmed death 1 (PD-1) blockade pembrolizumab. Differentially expressed genes associated with clinical outcomes were identified and further analyzed using gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Gene signature scores were calculated by single sample Gene Set Enrichment Analysis (ssGSEA). The infi

SUBMITTER: Cao Q 

PROVIDER: S-EPMC10334491 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature