Screening of placenta accreta spectrum disorder using maternal serum biomarkers and clinical indicators: a case-control study.

ABSTRACT:

Background

Placenta accreta spectrum (PAS) disorder is a major cause of postpartum hemorrhage-associated maternal and fetal death, and novel methods for PAS screening are urgently needed for clinical application.

Methods

The purpose of this study was to develop new methods for PAS screening using serum biomarkers and clinical indicators. A total of 95 PAS cases and 137 controls were enrolled in a case-control study as cohort one, and 44 PAS cases and 35 controls in a prospective nested case-control study were enrolled as cohort two. All subjects were pregnant women of Chinese Han population. Biomarkers for PAS from maternal blood samples were screened based on high-throughput immunoassay and were further validated in three phases of cohort one. Screening models for PAS were

SUBMITTER: Zhou J 

PROVIDER: S-EPMC10334543 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature