Low-grade inflammation is associated with a heterogeneous lipoprotein subclass profile in an apparently healthy population sample.

ABSTRACT:

Background and aims

Prevention measures for cardiovascular diseases (CVD) have shifted their focus from lipoproteins to the immune system. However, low-grade inflammation and dyslipidemia are tightly entangled. The objective of this study was to assess the relations between a broad panel of inflammatory biomarkers and lipoprotein subclass parameters.

Methods

We utilized data from the population-based Study of Health in Pomerania (SHIP-TREND, n = 403). Plasma concentrations of 37 inflammatory markers were measured by a bead-based assay. Furthermore, we employed nuclear magnetic resonance spectroscopy to measure total cholesterol, total triglycerides, total phospholipids as well as the fractional concentrations of cholesterol, triglycerides, phospholipids, ApoA1, ApoA2 and Apo

SUBMITTER: Pontzen DL 

PROVIDER: S-EPMC10334607 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature