Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals.

ABSTRACT:

Background

Frailty is an intermediate and reversible geriatric syndrome that often precedes dependence. Therefore, its identification is essential to prevent dependence. Several molecules have been proposed as biomarkers of frailty, but none of them have reached clinical practice. Recently, circular RNAs have emerged as new non-coding RNAs. Their regulatory role together with their high stability in biofluids makes them good candidates as biomarkers for various processes, but, to date, no study has characterized the expression of circRNA in frailty.

Results

We studied RNA from leukocytes of 35 frails and 35 robust individuals. After RNA-Sequencing, circRNA detection was performed by CIRI2 and Circexplorer2 and differential expression analysis by DESeq2. Validation was perfor

SUBMITTER: Iparraguirre L 

PROVIDER: S-EPMC10334614 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature