Dynamic alteration of intrinsic properties of the cerebellar Purkinje cell during the motor memory consolidation.

ABSTRACT: Intrinsic plasticity of the cerebellar Purkinje cell (PC) plays a critical role in motor memory consolidation. However, detailed changes in their intrinsic properties during memory consolidation are not well understood. Here, we report alterations in various properties involved in intrinsic excitability, such as the action potential (AP) threshold, AP width, afterhyperpolarization (AHP), and sag voltage, which are associated with the long-term depression of intrinsic excitability following the motor memory consolidation process. We analyzed data recorded from PCs before and 1, 4, and 24 h after cerebellum-dependent motor learning and found that these properties underwent dynamic changes during the consolidation process. We further analyzed data from PC-specific STIM1 knockout (STIM1^PK

SUBMITTER: Jang DC 

PROVIDER: S-EPMC10334628 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature