MiR-183-5p promotes migration and invasion of prostate cancer by targeting TET1.

ABSTRACT:

Background

Prostate cancer (PCa) is one of the common malignant tumors worldwide. MiR-183-5p has been reported involved in the initiation of human PCa, this study aimed to investigate whether miR-183-5p affects the development of prostate cancer.

Methods

In this study, we analyzed the expression of miR-183-5p in PCa patients and its correlation with clinicopathological parameters based on TCGA data portal. CCK-8, migration assay and invasion and wound-healing assay were performed to detect proliferation, migration and invasion in PCa cells.

Results

We found the expression of miR-183-5p was significantly increased in PCa tissues, and high expression of miR-183 was positively associated with poor prognosis of PCa patients. Over-expression of miR-183-5p promoted the migr

SUBMITTER: Feng Y 

PROVIDER: S-EPMC10334645 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature