Depression Promotes Gastroesophageal Reflux Disease: New Evidence Based on Mendelian Randomization.

ABSTRACT:

Background

Although observational studies have reported that depression is a risk factor for gastroesophageal reflux disease, it is difficult to determine the potential causal correlation. Thus, this study investigated the causal relevance of depression for gastroesophageal reflux disease using Mendelian randomization and provided new evidence for their association.

Methods

Based on data from the UK Biobank, we assessed the causality of the 2 diseases by analyzing 135 458 severe depressive disorder cases and 41 024 gastroesophageal reflux disease cases. The causal inference was assessed using inverse-variance weighting, weighted median, Mendelian randomization-Egger, and weighted median methods. Simultaneously, pleiotropy and sensitivity analyses were used for quality contro

SUBMITTER: Chen G 

PROVIDER: S-EPMC10334698 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature