A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic.

ABSTRACT: Ultrasound has long been identified as a promising, non-invasive modality for improving ocular drug delivery across a range of indications. Yet, with 20 years of learnings behind us, clinical translation remains limited. To help address this, and in accordance with PRISMA guidelines, the various mechanisms of ultrasound-mediated ocular drug delivery have been appraised, ranging from first principles to emergent applications spanning both ex vivo and in vivo models. The heterogeneity of study methods precluded meta-analysis, however an extensive characterisation of the included studies allowed for semi-quantitative and qualitative assessments. Methods: In this review, we reflected on study quality of reporting, and risk of bias (RoB) using the latest Animal Research: Re

SUBMITTER: Rad IJ 

PROVIDER: S-EPMC10334839 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature