IntEnzyDB: an Integrated Structure-Kinetics Enzymology Database.

ABSTRACT: Data-driven modeling has emerged as a new paradigm for biocatalyst design and discovery. Biocatalytic databases that integrate enzyme structure and function data are in urgent need. Here we describe IntEnzyDB as an integrated structure-kinetics database for facile statistical modeling and machine learning. IntEnzyDB employs a relational database architecture with a flattened data structure, which allows rapid data operation. This architecture also makes it easy for IntEnzyDB to incorporate more types of enzyme function data. IntEnzyDB contains enzyme kinetics and structure data from six enzyme commission classes. Using 1050 enzyme structure-kinetics pairs, we investigated the efficiency-perturbing propensities of mutations that are close or distal to the active site. The statistical result

SUBMITTER: Yan B 

PROVIDER: S-EPMC10335264 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature