Retinal organoids provide unique insights into molecular signatures of inherited retinal disease throughout retinogenesis.

ABSTRACT: The demand for induced pluripotent stem cells (iPSC)-derived retinal organoid and retinal pigment epithelium (RPE) models for the modelling of inherited retinopathies has increased significantly in the last decade. These models are comparable with foetal retinas up until the later stages of retinogenesis, expressing all of the key neuronal markers necessary for retinal function. These models have proven to be invaluable in the understanding of retinogenesis, particular in the context of patient-specific diseases. Inherited retinopathies are infamously described as clinically and phenotypically heterogeneous, such that developing gene/mutation-specific animal models in each instance of retinal disease is not financially or ethically feasible. Further to this, many animal models are insuffic

SUBMITTER: Watson A 

PROVIDER: S-EPMC10335378 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature