Restrictive versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury (RELIEVE-AKI): a pilot clinical trial protocol.

ABSTRACT:

Introduction

Observational studies have linked slower and faster net ultrafiltration (UF_NET) rates during kidney replacement therapy (KRT) with mortality in critically ill patients with acute kidney injury (AKI) and fluid overload. To inform the design of a larger randomised trial of patient-centered outcomes, we conduct a feasibility study to examine restrictive and liberal approaches to UF_NET during continuous KRT (CKRT).

Methods and analysis

This study is an investigator-initiated, unblinded, 2-arm, comparative-effectiveness, stepped-wedged, cluster randomised trial among 112 critically ill patients with AKI treated with CKRT in 10 intensive care units (ICUs) across 2 hospital systems. In the first 6 months, all ICUs started with a liberal UF_NET

SUBMITTER: Murugan R 

PROVIDER: S-EPMC10335418 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature