Study protocol: randomised controlled trial of conditioned open-label placebo (COLP) for perioperative pain management in patients with head and neck cancer.

ABSTRACT:

Introduction

Patients with head and neck cancer have a substantial risk of chronic opioid dependence following surgery due to pain and psychosocial consequences from both the disease process and its treatments. Conditioned open-label placebos (COLPs) have been effective for reducing the dose of active medication required for a clinical response across a wide range of medical conditions. We hypothesise that the addition of COLPs to standard multimodal analgesia will be associated with reduced baseline opioid consumption by 5 days after surgery in comparison to standard multimodal analgesia alone in patients with head and neck cancer.

Methods and analysis

This randomised controlled trial will evaluate the use of COLP for adjunctive pain management in patients with head and nec

SUBMITTER: Trakimas DR 

PROVIDER: S-EPMC10335570 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature