Disparities in cancer genetics care by race/ethnicity among pan-cancer patients with pathogenic germline variants.

ABSTRACT:

Background

Germline risk assessment is increasing as part of cancer care; however, disparities in subsequent genetic counseling are unknown.

Methods

Pan-cancer patients were prospectively consented to tumor-normal sequencing via custom next generation sequencing panel (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) inclusive of germline analysis of ≥76 genes from January 2015 through December 2019 (97.5% research nonbillable) with protocol for genetics referral. Rates of pathogenic/likely pathogenic germline variants (PVs) and downstream counseling were compared across ancestry groups (mutually exclusive groups based on self-reported race/ethnicity and Ashkenazi Jewish [AJ] heritage) using nonparametric tests and multivariable logistic r

SUBMITTER: Liu YL 

PROVIDER: S-EPMC10335605 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature