Urinary arsenic and spontaneous pregnancy loss - a hypothesis-generating case-control investigation in western Romania.

ABSTRACT: Arsenic occurs as a natural contaminant of drinking water supplies in arsenic endemic areas, posing a threat to public health. Our aim was to evaluate the relationship between urinary arsenic concentrations and spontaneous pregnancy loss in a population with low-moderate level drinking water arsenic exposure (mostly <10 μg/L). We enrolled 150 women with incident spontaneous pregnancy losses and 150 controls with ongoing pregnancies matched by gestational age. We measured arsenic species in urine using high performance liquid chromatography paired to inductively coupled plasma mass spectrometry. Urinary arsenic was not related to spontaneous pregnancy loss in conditional logistic regression models adjusted for confounding factors. However, a 10 μg/L increase in urinary arsenic (III + V) sal

SUBMITTER: Neamtiu IA 

PROVIDER: S-EPMC10335628 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature