Identification of a novel cord blood NK cell subpopulation expressing functional programmed death receptor-1.

ABSTRACT:

Background

Natural Killer cells (NKs) represent the innate counterpart of TCRαβ lymphocytes and are characterized by a high anti-tumor and an anti-viral cytotoxic activity. Recently, it has been demonstrated that NKs can express PD-1 as an additional inhibitory receptor. Specifically, PD-1 was identified on a subpopulation of terminally differentiated NKs from healthy adults with previous HCMV infection. So far it is unknown whether PD-1 appears during NK-cell development and whether this process is directly or indirectly related to HCMV infection.

Methods

In this study, we analyzed the expression and function of PD-1 on Cord Blood derived NKs (CB-NKs) on a large cohort of newborns through multiparametric cytofluorimetric analysis.

Results

We identified PD-1 on CB-NKs

SUBMITTER: Greppi M 

PROVIDER: S-EPMC10335745 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature