Comparative analysis of calcified soft tissues revealed shared deregulated pathways.

ABSTRACT:

Introduction

Calcification of soft tissues is a common age-related pathology that primarily occurs within vascular tissue. The mechanisms underlying pathological calcification in humans and tissue specificity of the process is still poorly understood. Previous studies examined calcified tissues on one to one basis, thus preventing comparison of deregulated pathways across tissues.

Purpose

This study aimed to establish common and tissue-specific changes associated with calcification in aorta, artery tibial, coronary artery and pituitary gland in subjects from the Genotype-Tissue Expression (GTEx) dataset using its RNA sequencing and histological data.

Methods

We used publicly available data from the GTEx database https://gtexportal.org/home/aboutGTEx. All GTEx tissue s

SUBMITTER: Ibragimova AG 

PROVIDER: S-EPMC10335799 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature