A novel signature of aging-related genes associated with lymphatic metastasis for survival prediction in patients with bladder cancer.

ABSTRACT:

Background

The predominant and most prevalent form of metastatic bladder cancer (BCa) is lymphatic metastasis, which is associated with a highly dismal prognosis for patients. Aging-related genes (ARGs) are believed to contribute significantly to tumor development. However, the effect of ARGs on lymphatic metastasis of BCa is unclear. This research sought to establish a prognosis model based on ARGs associated with lymphatic metastasis in BCa.

Methods

We downloaded BCa data from the TCGA and GEO databases and ARGs from the Aging Atlas database. The least absolute shrinkage and selection operator (LASSO) approach was applied to obtain the characteristic ARGs of risk signature in the TCGA cohort. Verification was done using the GSE13507 dataset. The R package 'ConsensusCluster

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC10335803 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature