Effects of dutasteride and tamsulosin on penile morphology in a rodent model.

ABSTRACT:

Purpose

To evaluate the penile morphology after the isolated and combined administration of dutasteride and tamsulosin in a rodent model.

Materials and methods

Forty male rats were assigned into the following groups: Control group (C, receiving distilled water, n=10); Dutasteride group (D, receiving 0.5 mg/Kg/day of dutasteride, n=10); Tamsulosin group (T, receiving 0.4 mg/Kg/day of tamsulosin, n=10); and Dutasteride associated with Tamsulosin group (DT, receiving both drugs n = 10). All drugs were administered via oral gavage. After 40 days, the animals were submitted to euthanasia and their penises were collected for histomorphometric analyses. Data were compared using one-way ANOVA followed by Bonferroni's post-test, considering p<0.05 as significant.

Results

The s

SUBMITTER: da Silva MHA 

PROVIDER: S-EPMC10335897 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature