Bioconversion of vitamin D₃ into calcitriol by Actinomyces hyovaginalis isolate CCASU- A11-2.

ABSTRACT: Vitamin D₃ is a fat-soluble prohormone that is activated inside the liver to produce 25-hydroxyvitamin D₃ (calcidiol), and in the kidney to produce the fully active 1α, 25-dihydroxy vitamin D₃ (calcitriol). A previous work piloted in our laboratory, resulted in a successful recovery of a local soil-promising Actinomyces hyovaginalis isolate CCASU-A11-2 capable of converting vitamin D₃ into calcitriol. Despite the rising amount of research on vitamin D₃ bioconversion into calcitriol, further deliberate studies on this topic can significantly contribute to the improvement of such a bioconversion process. Therefore, this work aimed to improve the bioconversion process, using the study isolate, in a 14 L laboratory fermenter (4 L fermentat

SUBMITTER: Abbas AM 

PROVIDER: S-EPMC10335987 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature