Microparticles with tunable, cell-like properties for quantitative acoustic mechanophenotyping.

ABSTRACT: Mechanical properties of biological cells have been shown to correlate with their biomolecular state and function, and therefore methods to measure these properties at scale are of interest. Emerging microfluidic technologies can measure the mechanical properties of cells at rates over 20,000 cells/s, which is more than four orders of magnitude faster than conventional instrumentation. However, precise and repeatable means to calibrate and test these new tools remain lacking, since cells themselves are by nature variable. Commonly, microfluidic tools use rigid polymer microspheres for calibration because they are widely available in cell-similar sizes, but conventional microspheres do not fully capture the physiological range of other mechanical properties that are equally important to dev

SUBMITTER: Dubay R 

PROVIDER: S-EPMC10336031 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature