Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression.

ABSTRACT: Depression is a common mental disease, with some patients exhibiting ideas and behaviors such as self-harm and suicide. The drugs currently used to treat depression have not achieved good results. It has been reported that metabolites produced by intestinal microbiota affect the development of depression. In this study, core targets and core compounds were screened by specific algorithms in the database, and three-dimensional structures of these compounds and proteins were simulated by molecular docking and molecular dynamics software to further study the influence of intestinal microbiota metabolites on the pathogenesis of depression. By analyzing the RMSD gyration radius and RMSF, it was finally determined that NR1H4 had the best binding effect with genistein. Finally, according to Lipin

SUBMITTER: Teng F 

PROVIDER: S-EPMC10336060 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature