BMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study.

ABSTRACT: Previous studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations is limited. Here, we investigated the association between BMI and well-being in people of (a) East Asian and (b) European ancestry in the China Kadoorie Biobank (CKB) and UK Biobank (UKB), respectively. Mendelian randomisation (MR) methods were used to test the relationship between BMI with (a) health satisfaction and (b) life satisfaction. One-sample MR enabled us to test effects in men and women separately and to test the role of cultural contexts by stratifying our analyses by urban and rural home location in both China and the UK. Further, we implemented a control function method t

SUBMITTER: O'Loughlin J 

PROVIDER: S-EPMC10336095 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature