Soft molecularly imprinted nanoparticles with simultaneous lossy mode and surface plasmon multi-resonances for femtomolar sensing of serum transferrin protein.

ABSTRACT: The simultaneous interrogation of both lossy mode (LMR) and surface plasmon (SPR) resonances was herein exploited for the first time to devise a sensor in combination with soft molecularly imprinting of nanoparticles (nanoMIPs), specifically entailed of the selectivity towards the protein biomarker human serum transferrin (HTR). Two distinct metal-oxide bilayers, i.e. TiO₂-ZrO₂ and ZrO₂-TiO₂, were used in the SPR-LMR sensing platforms. The responses to binding of the target protein HTR of both sensing configurations (TiO₂-ZrO₂-Au-nanoMIPs, ZrO₂-TiO₂-Au-nanoMIPs) showed femtomolar HTR detection, LODs of tens of fM and K_Dapp ~ 30 fM. Selectivity for HTR was demonstrated. The SPR interrogation w

SUBMITTER: Arcadio F 

PROVIDER: S-EPMC10336098 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature