Intergenerational and early life associations of the gut microbiome and stress-related symptomatology among Black American mothers and children.

ABSTRACT: Recent evidence suggests that maternal childhood adversity may have an intergenerational impact, with children of adversity-exposed mothers exhibiting elevated symptoms of psychopathology. At the same time, many children demonstrate resilience to these intergenerational effects. Among the variety of factors that likely contribute to resilience, the composition of the gut microbiome may play a role in buffering the negative impacts of trauma and stress. The current prospective cohort study tested the novel hypothesis that offspring gut microbiome composition is a potential moderator in the relationship between maternal exposure to childhood adversity and offspring symptomatology (i.e., internalizing, externalizing, and posttraumatic stress symptoms). Maternal childhood adversity was self-re

SUBMITTER: McKenna BG 

PROVIDER: S-EPMC10336162 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature