Chronic early life stress alters the neuroimmune profile and functioning of the developing zebrafish gut.

ABSTRACT: Chronic early life stress (ELS) potently impacts the developing central nervous and immune systems and is associated with the onset of gastrointestinal disease in humans. Though the gut-brain axis is appreciated to be a major target of the stress response, the underlying mechanisms linking ELS to gut dysfunction later in life is incompletely understood. Zebrafish are a powerful model validated for stress research and have emerged as an important tool in delineating neuroimmune mechanisms in the developing gut. Here, we developed a novel model of ELS and utilized a comparative transcriptomics approach to assess how chronic ELS modulated expression of neuroimmune genes in the developing gut and brain. Zebrafish exposed to ELS throughout larval development exhibited anxiety-like behavior and

SUBMITTER: Graves CL 

PROVIDER: S-EPMC10336164 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature