Urinary TNF-α as a potential biomarker for chronic primary low back pain.

ABSTRACT:

Introduction

Over two thirds of individuals with low back pain (LBP) may experience recurrent or persistent symptoms in the long term. Yet, current data do not allow to predict who will develop chronic low back pain and who will recover from an acute episode. Elevated serum levels of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) have been associated with poor recovery and persistent pain following an acute episode of LBP. Inflammatory cytokines may also mediate mechanisms involved in nociplastic pain, and thus, have significant implications in chronic primary low back pain (CPLBP).

Methods

This study aimed to investigate the potential of urinary TNF-α levels for predicting outcomes and characterizing clinical features of CPLBP patients. Twenty-four patients wi

SUBMITTER: Gevers-Montoro C 

PROVIDER: S-EPMC10336221 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature