Hypovirus infection induces proliferation and perturbs functions of mitochondria in the chestnut blight fungus.

ABSTRACT:

Introduction

The chestnut blight fungus, Cryphonectria parasitica, and hypovirus have been used as a model to probe the mechanism of virulence and regulation of traits important to the host fungus. Previous studies have indicated that mitochondria could be the primary target of the hypovirus.

Methods

In this study, we report a comprehensive and comparative study comprising mitochondrion quantification, reactive oxygen species (ROS) and respiratory efficiency, and quantitative mitochondrial proteomics of the wild-type and virus-infected strains of the chestnut blight fungus.

Results and discussion

Our data show that hypovirus infection increases the total number of mitochondria, lowers the general ROS level, and increases mitochondrial respiratory efficiency. Qu

SUBMITTER: Wang J 

PROVIDER: S-EPMC10336323 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature