Functional MRI-specific alterations in frontoparietal network in mild cognitive impairment: an ALE meta-analysis.

ABSTRACT:

Background

Mild cognitive impairment (MCI) depicts a transitory phase between healthy elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment. Some functional MRI (fMRI) research indicated that the frontoparietal network (FPN) could be an essential part of the pathophysiological mechanism of MCI. However, damaged FPN regions were not consistently reported, especially their interactions with other brain networks. We assessed the fMRI-specific anomalies of the FPN in MCI by analyzing brain regions with functional alterations.

Methods

PubMed, Embase, and Web of Science were searched to screen neuroimaging studies exploring brain function alterations in the FPN in MCI using fMRI-related indexes, including the amplitude of low-frequency fluctuation,

SUBMITTER: Yang X 

PROVIDER: S-EPMC10336325 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature