Intraocular complement activation is related to retinal vascular and neuronal degeneration in myopic retinopathy.

ABSTRACT:

Purpose

To investigate the relationship between the intraocular levels of complement proteins and myopia-related retinal neuronal and vascular degeneration.

Methods

Aqueous humour from 147 myopic patients, including 60 low-myopia and 87 high-myopia were collected during Implantable Collamer Lens implantation surgery. All participants received comprehensive ophthalmic examinations, including logMAR best corrected visual acuity, axial length measurement, fundus photography and ocular B-scan ultrasonography. The myopic eyes were further classified into simple myopia (SM, n = 78), myopic posterior staphyloma (PS, n = 39) and PS with myopic chorioretinal atrophy (PS + CA, n = 30). Retinal thickness and vascular density in the macula (6 mm × 6 mm) and optic ne

SUBMITTER: Zeng L 

PROVIDER: S-EPMC10336352 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature