Late-onset enteric virus infection associated with hepatitis (EVAH) in transplanted SCID patients.

ABSTRACT:

Background

Allogenic hematopoietic stem cell transplantation (HSCT) and gene therapy (GT) are potentially curative treatments for severe combined immunodeficiency (SCID). Late-onset posttreatment manifestations (such as persistent hepatitis) are not uncommon.

Objective

We sought to characterize the prevalence and pathophysiology of persistent hepatitis in transplanted SCID patients (SCIDH+) and to evaluate risk factors and treatments.

Methods

We used various techniques (including pathology assessments, metagenomics, single-cell transcriptomics, and cytometry by time of flight) to perform an in-depth study of different tissues from patients in the SCIDH+ group and corresponding asymptomatic similarly transplanted SCID patients without hepatitis (SCIDH-).

Results

SUBMITTER: Riller Q 

PROVIDER: S-EPMC10336473 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature