Synthetic transformation of 6-Fluoroimidazo[1,2-a]Pyridine-3-carbaldehyde into 6-Fluoroimidazo[1,2-a]Pyridine-Oxazole Derivatives: In vitro urease inhibition and in silico study.

ABSTRACT:

Purpose

Ulcer is a serious disease that is caused due to different bacteria and over usage of various NSAIDs which caused to reduce the defensive system of stomach. Therefore, some novel series are needed to overcome these issues.

Methods

Oxazole-based imidazopyridine scaffolds (4a-p) were designed and synthesized by two step reaction protocol and then subjected to urease inhibition profile (in vitro). All the newly afforded analogs (4a-p) were found potent and demonstrated moderate to significant inhibition profile.

Results

Particularly, the analogs 4i (IC₅₀ = 5.68 ± 1.66 μM), 4o (IC₅₀ = 7.11 ± 1.24 μM), 4 g (IC₅₀ = 9.41 ± 1.19 μM) and 4 h (IC₅₀ = 10.45 ± 2.57 μM) were identi

SUBMITTER: Hussain R 

PROVIDER: S-EPMC10336670 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature