Vasoactive intestinal peptide exerts therapeutic action by regulating PTEN in a model of Sjogren's disease.

ABSTRACT:

Introduction

Sjögren's disease (SjD) is a chronic autoimmune disease characterized by the loss of the secretory function of the exocrine glands. At present, drugs that can both correct the immune imbalance and improve exocrine gland function are needed. Meanwhile, vasoactive intestinal peptide (VIP) has been reported as a candidate with anti-inflammatory and immunoregulatory properties for treating autoimmune diseases.

Methods

Nonobese diabetic (NOD) mice and the primary splenic lymphocyte cells (SPLCs) were used to construct the SS model. The therapeutic effects of VIP for SjD by evaluating water consumption, histopathology, T cell subsets, and related cytokines. RT-qPCR and Western blot analysis were used to identify the expression of the PTEN/PI3K/AKT pathway.

Results<

SUBMITTER: Li Y 

PROVIDER: S-EPMC10336679 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature