Ontology highlight
ABSTRACT:
SUBMITTER: Chang MJ
PROVIDER: S-EPMC10336728 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Chang Min-Ju MJ Ollivault-Shiflett Morgane M Schuman Richard R Ngoc Nguyen Son S Kaltashov Igor A IA Bobst Cedric C Rajagopal Shalini P SP Przedpelski Amanda A Barbieri Joseph T JT Lees Andrew A
Vaccine 20220722 35
Tetanus toxoid (TTxd), developed over 100 years ago, is a clinically effective, legacy vaccine against tetanus. Due to the extreme potency of native tetanus toxin, manufacturing and regulatory efforts often focus on TTxd production, standardization, and safety, rather than product modernization. Recently, a genetically detoxified, full-length tetanus toxin protein (8MTT) was reported as a tetanus vaccine alternative to TTxd (Przedpelski et al. mBio, 2020). Here we describe the production of 8MTT ...[more]