3D In Vitro Models for Investigating the Role of Stiffness in Cancer Invasion.

ABSTRACT:

Background

Tumorigenesis is attributed to the interactions of cancer cells with the tumor microenvironment through both biochemical cues and physical stimuli. Increased matrix deposition and realignment of the collagen fibers are detected by cancer cells, inducing epithelial-to-mesenchymal transition, which in turn stimulates cell motility and invasiveness.

Methods

This review provides an overview of current research on the role of the physical microenvironment in cancer invasion. This was achieved by using a systematic approach and providing meta-analyses. Particular focus was placed on in vitro three-dimensional models of epithelial cancers. We investigated questions such as the effect of matrix stiffening, activation of stromal cells, and identified potential advan

SUBMITTER: Micalet A 

PROVIDER: S-EPMC10336749 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature