Preparation and Synthetic Applications of Phototropone.

ABSTRACT: An optimized multigram-scale route to phototropone (bicyclo[3.2.0]hepta-2,6-dien-7-one) is reported via the 4-π-photocyclization of tropone complexed to Lewis acid. Phototropone is a highly versatile molecular building block, and its conversion into 18 novel derivatives using standard transformations is demonstrated, allowing access to a variety of rigid bicyclic scaffolds.

SUBMITTER: Lowe JP 

PROVIDER: S-EPMC10337036 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature