Identification of immune-related target and prognostic biomarkers in PBMC of hepatocellular carcinoma.

ABSTRACT:

Background

 Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and is characterized by insidious onset, rapid progression, and poor prognosis. Immunotherapy is a first-line treatment for advanced HCC. The identification of immune-related prognostic markers may be an effective strategy to predict and improve clinical response rate of immunotherapy.

Methods

 The DESeq2, edgeR, and limma R packages were used to compare the transcriptomes of HCC with different prognoses. Cancer-related databases such as UALCAN, TNMplot, GEPIA, muttarget and Human Protein Atlas (HPA), and the Kaplan-Meier Plotter platform were used to analyze the relationship between CLDN18 and the clinical characteristics, as well as prognosis of HCC. The co-expressed g

SUBMITTER: Hu R 

PROVIDER: S-EPMC10337054 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature