LPS binding protein and activation signatures are upregulated during asthma exacerbations in children.

ABSTRACT: Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children (n = 19) during acute virus-associated exacerbations and later during convalescence. Systems level analyses were employed to identify coexpression networks and infer the drivers of these networks, and validation was subsequently obtained via independent samples from asthmatic children. During exacerbations, PBMC exhibited significant changes in immune cell abundan

SUBMITTER: Jones AC 

PROVIDER: S-EPMC10337076 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature