Chronic jetlag accelerates pancreatic neoplasia in conditional Kras-mutant mice.

ABSTRACT: Misalignment of the circadian clock compared to environmental cues causes circadian desynchrony, which is pervasive in humans. Clock misalignment can lead to various pathologies including obesity and diabetes, both of which are associated with pancreatic ductal adenocarcinoma - a devastating cancer with an 80% five-year mortality rate. Although circadian desynchrony is associated with an increased risk of several solid-organ cancers, the correlation between clock misalignment and pancreas cancer is unclear. Using a chronic jetlag model, we investigated the impact of clock misalignment on pancreas cancer initiation in mice harboring a pancreas-specific activated Kras mutation. We found that chronic jetlag accelerated the development of pancreatic cancer precursor lesions, with a conc

SUBMITTER: Schwartz PB 

PROVIDER: S-EPMC10337099 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature