Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy.

ABSTRACT:

Background

The majority of women with epithelial ovarian cancer (OvCa) are diagnosed with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized non-infectious pandemic that increases OvCa incidence, enhances metastatic success and reduces survival. We have previously demonstrated a link between obesity and OvCa metastatic success in a diet-induced obesity mouse model wherein a significantly enhanced tumor burden was associated with a decreased M1/M2 tumor-associated macrophage ratio (Liu Y et al. Can, Res. 2015; 75:5046-57).

Methods

The objective of this study was to use pre-clinical murine models of diet-induced obesity to evaluate the effect of a high fat diet (HFD) on response to standard of care chemotherapy and to assess obesity-associa

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10337170 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature