Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults.

ABSTRACT:

Background

Gene expression is dysregulated in Alzheimer's disease (AD) patients, both in peripheral blood and post mortem brain. We investigated peripheral whole-blood gene (co)expression to determine molecular changes prior to symptom onset.

Methods

RNA was extracted and sequenced for 65 cognitively healthy F-PACK participants (65 (56-80) years, 34 APOE4 non-carriers, 31 APOE4 carriers), at baseline and follow-up (interval: 5.0 (3.4-8.6) years). Participants received amyloid PET at both time points and amyloid rate of change derived. Accumulators were defined with rate of change ≥ 2.19 Centiloids. We performed differential gene expression and weighted gene co-expression network analysis to identify differentially expressed genes and networks of co-expressed genes, respectiv

SUBMITTER: Luckett ES 

PROVIDER: S-EPMC10337180 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature