Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population.

ABSTRACT:

Background

The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about the relationship between oral bacteria and respiratory outcomes in the general population. We aimed to describe the associations between oral bacteria, lung function, and lung inflammation in a community-based population.

Methods

Oral (gingival) samples were collected concurrently with spirometry tests in 477 adults (47% males, median age 28 years) from the RHINESSA study in Bergen, Norway. Bacterial DNA from the 16S rRNA gene from gingival fluid were sequenced by Illumina^®MiSeq. Lung function was measured using spirometry and measurement of fraction

SUBMITTER: Shigdel R 

PROVIDER: S-EPMC10337198 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature