Lipid signatures of West Nile virus infection unveil alterations of sphingolipid metabolism providing novel biomarkers.

ABSTRACT: West Nile virus (WNV) is a neurotropic flavivirus transmitted by the bites of infected mosquitoes. Severe forms of West Nile disease (WND) can curse with meningitis, encephalitis or acute flaccid paralysis. A better understanding of the physiopathology associated with disease progression is mandatory to find biomarkers and effective therapies. In this scenario, blood derivatives (plasma and serum) constitute the more commonly used biofluids due to its ease of collection and high value for diagnostic purposes. Therefore, the potential impact of this virus in the circulating lipidome was addressed combining the analysis of samples from experimentally infected mice and naturally WND patients. Our results unveil dynamic alterations in the lipidome that define specific metabolic fingerprints of

SUBMITTER: Mingo-Casas P 

PROVIDER: S-EPMC10337513 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature