Direct hydrogen selenide (H₂Se) release from activatable selenocarbamates.

ABSTRACT: Hydrogen selenide (H₂Se) is a possible bioregulator, potential gasotransmitter, and important precursor in biological organoselenium compound synthesis. Early tools for H₂Se research have benefitted from available mechanistic understanding of analogous small molecules developed for detecting or delivering H₂S. A now common approach for H₂S delivery is the use of small molecule thiocarbamates that can be engineered to release COS, which is quickly converted to H₂S by carbonic anhydrase. To expand our understanding of the chemical underpinnings that enable H₂Se delivery, we investigated whether selenocarbamates undergo similar chemistry to release carbonyl selenide (COSe). Using both light- and hydrolysis-activated systems, we

SUBMITTER: Newton TD 

PROVIDER: S-EPMC10337719 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature