Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.

ABSTRACT:

Objective

Inflammation is recognized as a contributor in the development of pulmonary arterial hypertension (PAH), and the recruitment and functional capacity of immune cells are well-orchestrated by chemokines and their receptors. This study is aimed at identification of critical chemokines in the progression of PAH via transcriptomic analysis.

Methods

Differentially expressed genes (DEGs) from lungs of PAH patients were achieved compared to controls based on Gene Expression Omnibus (GEO) database. Gene set enrichment analysis (GSEA) was applied for functional annotation and pathway enrichement. The abundance of immune cells was estimated by the xCell algorithm. Weighted correlation network analysis (WGCNA) was used to construct a gene expression network, based on wh

SUBMITTER: Jiang CY 

PROVIDER: S-EPMC10337759 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature