Individualized network analysis reveals a link between the gut microbiome, diet intervention and Gestational Diabetes Mellitus.

ABSTRACT: Gestational Diabetes Mellitus (GDM), a serious complication during pregnancy which is defined by abnormal glucose regulation, is commonly treated by diabetic diet and lifestyle changes. While recent findings place the microbiome as a natural mediator between diet interventions and diverse disease states, its role in GDM is still unknown. Here, based on observation data from healthy pregnant control group and GDM patients, we developed a new network approach using patterns of co-abundance of microorganism to construct microbial networks that represent human-specific information about gut microbiota in different groups. By calculating network similarity in different groups, we analyze the gut microbiome from 27 GDM subjects collected before and after two weeks of diet therapy compared with 3

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10337958 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature